Am.J.Respir.Crit.Care Med. 2009;23(3):906-914. The effects of oral creatine supplementation on performance in single and repeated sprint swimming. Davani-Davari D, Karimzadeh I, Ezzatzadegan-Jahromi S, Sagheb MM. View abstract. View abstract. Interstitial nephritis in a patient taking creatine. J Med Food 2014;17(9):1022-6. Clin Chem. Huso, M. E., Hampl, J. S., Johnston, C. S., and Swan, P. D. Creatine supplementation influences substrate utilization at rest.  |  View abstract. Oral creatine supplementation (CR) in COPD exercise training: a randomized, double-blind, placebo (PL) controlled trial [Abstract]. View abstract. Med Sci Sports Exerc 1997;29(5 Suppl):S145. Some research shows that taking creatine daily does not improve lung function. View abstract. View abstract. Muscle breakdown. Int J Sport Nutr. Effect of low dose, short-term creatine supplementation on muscle power output in elite youth soccer players. Leader, A., Amital, D., Rubinow, A., and Amital, H. An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome. This creatine production occurs in the liver, pancreas and kidneys. J.Strength.Cond.Res. Early research shows that taking creatine by mouth daily for 2 months does not improve symptoms or mental function in people with schizophrenia. View abstract. The use of exogenous creatine phosphate for myocardial protection in patients undergoing coronary artery bypass surgery. Walter, A. Kamber M, Koster M, Kreis R, et al. View abstract. 2008;16(1):15-22. J Sports Med Phys Fitness. View abstract. Naderi A, de Oliveira EP, Ziegenfuss TN, Willems MT. Jowko E, Ostaszewski P, Jank M, et al. Parashos, S. A., Swearingen, C. J., Biglan, K. M., Bodis-Wollner, I., Liang, G. S., Ross, G. W., Tilley, B. C., and Shulman, L. M. Determinants of the timing of symptomatic treatment in early Parkinson disease: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience. de Souza E Silva A, Pertille A, Reis Barbosa CG, et al. 2001;33(11):1876-1881. Medications that can harm the kidneys (Nephrotoxic Drugs) interacts with CREATINE. Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport? Creatine supplementation during resistance training in older adults - a meta-analysis. Neurology 1999;52:854-7. Kilduff, L. P., Georgiades, E., James, N., Minnion, R. H., Mitchell, M., Kingsmore, D., Hadjicharlambous, M., and Pitsiladis, Y. P. The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. View abstract. Would you like email updates of new search results? Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial. J Appl Physiol 1996;81:232-7. 1997 Dec;83(6):2055-63 2011;25(7):1831-1838. View abstract. J.Strength.Cond.Res. View abstract. Rico-Sanz J, Mendez Marco MT. Muscle Nerve 1997;20:1502-9. View abstract. Comparison of creatine supplementation before versus after supervised resistance training in healthy older adults. Effect of creatine on performance of militarily relevant tasks and soldier health. J Appl.Physiol 2003;94(5):1910-1916. J Nutr Health Aging. Protection of ischemic myocardium by exogenous phosphocreatine. It doesn't seem to help when used in lower doses, as a single dose, or when used without exercise. Kaptsan A, Odessky A, Osher Y, Levine J. 1975;105(4):428-438. Larkin JG, Capell HA, Sturrock RD. Kerksick, C. M., Wilborn, C. D., Campbell, W. I., Harvey, T. M., Marcello, B. M., Roberts, M. D., Parker, A. G., Byars, A. G., Greenwood, L. D., Almada, A. L., Kreider, R. B., and Greenwood, M. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations. Acta Physiol Hung. Vandenberghe K, Van Hecke P, Van Leemputte M, et al. van Loon, L. J., Murphy, R., Oosterlaar, A. M., Cameron-Smith, D., Hargreaves, M., Wagenmakers, A. J., and Snow, R. Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. 2008;7(1):15-22. 2008;97(1):31-34. Terrillion, K. A., Kolkhorst, F. W., Dolgener, F. A., and Joslyn, S. J. Tarnopolsky, M. A. Renema, W. K., Schmidt, A., van Asten, J. J., Oerlemans, F., Ullrich, K., Wieringa, B., Isbrandt, D., and Heerschap, A. MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: validation of an animal model to study creatine deficiency. Derave, W., Eijnde, B. O., Verbessem, P., Ramaekers, M., Van Leemputte, M., Richter, E. A., and Hespel, P. Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans. View abstract. Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis. Lancet 1998;351:724. Ostojic SM, Stajer V, Vranes M, Ostojic J. Searching for a better formulation to enhance muscle bioenergetics: A randomized controlled trial of creatine nitrate plus creatinine vs. creatine nitrate vs. creatine monohydrate in healthy men. View abstract. Creatine Monohydrate Side Effects You shouldn't take too much creatine at once (stick to the recommendations on the packaging or ask your doctor), it can cause diarrhea, headache, nausea, and a few other unpleasant symptoms. Burke, D. G., Chilibeck, P. D., Parise, G., Candow, D. G., Mahoney, D., and Tarnopolsky, M. Effect of creatine and weight training on muscle creatine and performance in vegetarians. A rare, inherited disorder that causes muscle pain and cramping (McArdle disease). Int J Sports Med 2000;21:139-45. Your body may take some time to get used to creatine supplements. View abstract. View abstract. Gilliam JD, Hohzorn C, Martin D, Trimble MH. View abstract. Tarnopolsky, M. A., Mahoney, D. J., Vajsar, J., Rodriguez, C., Doherty, T. J., Roy, B. D., and Biggar, D. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Andreev NA, Andreeva TN, and Bichkov IV.  |  Green AL, Hultman E, Macdonald IA, et al. Throughout the years, there have been minimal negative side effects. Stevenson, S. W. and Dudley, G. A. Dietary creatine supplementation and muscular adaptation to resistive overload. 1989;35(8):1802-1803. Creatine: a review of efficacy and safety. Thorax 2005;60(7):531-537. 2008;31(3):141-150. Barnett C, Hinds M, Jenkins DG. View abstract. 2001;33(1):61-68. The New York Times. Sports Medicine, Training and Rehabilitation. Ganguly S, Jayappa S, Dash AK. 2009;96(3):325-336. Eur Heart J 1998;19:617-22. Clipboard, Search History, and several other advanced features are temporarily unavailable. View abstract. Cochrane.Database.Syst.Rev. Med Sci.Sports Exerc. Discusses the effects of creatine monohydrate, side effects, dangers and the actual benefits of creatine. Med.Sci.Sports Exerc. View abstract. But it doesn't improve mental ability. The thing is, these side effects are caused by not using creatine properly and can easily be avoided. View abstract. Fact: There is no data that shows creatine causes muscle cramps or dehydration. J Cardiovasc Surg (Torino) 1996;37:75-80. J Strength.Cond.Res 2005;19(2):260-264. Burke LM, Pyne DB, and Telford RD. Bipolar.Disord 2007;9(7):754-758. High levels of homocysteine in the blood (hyperhomocysteinemia). Am J Med Genet.A 2011;155A(12):2956-2963. Combined use of phosphocreatine and nifedipine for treatment of patients with acute myocardial infarction. Gordon A, Hultman E, Kaijser L, et al. One of the most common concerns about creatine supplementation is that it can cause dehydration or cramping, particularly in hot and humid environments. Pediatr.Res 1998;44(3):410-414. Neurology 5-25-2004;62(10):1771-1777. Ann Thorac Surg 1996;61:67-75. Ann.Neurol. The effect of creatine supplementation on two 700-m maximal running bouts. © 2005 - 2019 WebMD LLC. Easton, C., Calder, A., Prior, F., Dobinson, S., I'Anson, R., MacGregor, R., Mohammad, Y., Kingsmore, D., and Pitsiladis, Y. P. The effects of a novel "fluid loading" strategy on cardiovascular and haematological responses to orthostatic stress. J Frailty Aging. Food Sci Nutr. Short term (5 days), medium term (9 weeks) and long term (up to 5 years) oral creatine supplementation has been studied in small cohorts of athletes whose kidney function was monitored by clearance methods and urine protein excretion rate. 2004;18(1):168-173. Am.J.Emerg.Med. J Neurol. The effects of six weeks of creatine monohydrate supplementation in male and female track athletes. J Geriatr.Phys.Ther 2005;28(2):40-47. View abstract. The effect of creatine monohydrate loading on maximal intermittent exercise and sport-specific strength in well trained power-lifters. Nephrol.Dial.Transplant. FASEB J 1998;12:A652. Verhoeven, N. M., Guerand, W. S., Struys, E. A., Bouman, A. 2020;52(1):120-130. View abstract. The effects of creatine monohydrate loading on anaerobic performance and one-repetition maximum strength. Nutrition 2011;27(4):451-455. Teicher, B. Mol.Genet.Metab 2006;89(4):392-394. Lancet 1998;352:233-4. Depression. Neurology 2000;54:1848-50. View abstract. Zuniga, J. M., Housh, T. J., Camic, C. L., Hendrix, C. R., Mielke, M., Johnson, G. O., Housh, D. J., and Schmidt, R. J. Cholestatic jaundice as a result of combination designer supplement ingestion. An inherited disorder the affects brain development in girls (Rett syndrome). Heat intolerance 10. Bergnes G, Yuan W, Khandekar VS, et al. Cochrane.Database.Syst.Rev. Creatine supplementation does not alter neuromuscular recovery after eccentric exercise. 2009;20(8):673-679. Martin KJ, Chen SF, Clark GM, et al. View abstract. 2007;21(1):57-61. View abstract. Mil.Med 2001;166(11):996-1002. Effect of creatine supplementation on jumping performance in elite volleyball players. J Am.Diet.Assoc 1999;99(5):593-595. View abstract. Early research on the use of creatine by mouth in people with muscular dystrophy is not clear. Becque MD, Lochmann JD, Melrose DR. Amyotroph.Lateral.Scler. View abstract. Buford TW, Kreider RB, Stout JR, et al. Pharmacol Res. Ann Neurol 2003;53:437-45. . All rights reserved. Mercimek-Mahmutoglu, S., Connolly, M. B., Poskitt, K. J., Horvath, G. A., Lowry, N., Salomons, G. S., Casey, B., Sinclair, G., Davis, C., Jakobs, C., and Stockler-Ipsiroglu, S. Treatment of intractable epilepsy in a female with SLC6A8 deficiency. However, taking higher doses of creatine seem to make muscle pain worse. -, Med Sci Sports Exerc. View abstract. J Clin Psychiatry 2007;68:881-4. Low bone mass (osteopenia). Medicine & Science in Sports & Exercise 1996;28(5):81. (check all that apply), What factors are most important to you? Where did you or where do you plan to purchase this product? View abstract. Gastrointestinal disturbances and muscle cramps have been reported occasionally in healthy individuals, but the effects are anecdotal. Golini J, Jones WL. View abstract. Ziegenfuss, T. N., Rogers, M., Lowery, L., Mullins, N., Mendel, R., Antonio, J., and Lemon, P. Effect of creatine loading on anaerobic performance and skeletal muscle volume in NCAA Division I athletes. 2008;(1):CD006052. 2002;34(7):1176-1183. However, taking creatine seems to help maintain muscle mass and reduce the loss of muscle strength that is associated with having to wear a cast. View abstract. The effect of oral creatine supplementation on maximal exercise performance in competitive rowers. View abstract. View abstract. 2010;317(1-2):25-30. Satolli F and Marchesi G. Creatine phosphate in the rehabilitation of patients with muscle hypotonotrophy of the lower extremity. Lancet 9-21-1996;348(9030):789-790. 2009;51(5):404-407. Multiple sclerosis (MS). Side Effects of Creatine In appropriate doses, creatine is generally safe to take. Sempere, A., Fons, C., Arias, A., Rodriguez-Pombo, P., Merinero, B., Alcaide, P., Capdevila, A., Ribes, A., Duque, R., Eiris, J., Poo, P., Fernandez-Alvarez, E., Campistol, J., and Artuch, R. [Cerebral creatine deficiency: first Spanish patients harbouring mutations in GAMT gene]. Creatine supplementation and sprint training in cyclists: metabolic and performance effects. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. Bennett, T., Bathalon, G., Armstrong, D., III, Martin, B., Coll, R., Beck, R., Barkdull, T., O'Brien, K., and Deuster, P. A. Accessed March 12, 2017. A. Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism. Metabolism 2001;50(12):1429-1434. View abstract. Chilibeck, P. D., Chrusch, M. J., Chad, K. E., Shawn, Davison K., and Burke, D. G. Creatine monohydrate and resistance training increase bone mineral content and density in older men. Behav.Pharmacol. J Int Soc Sports Nutr. Can J Appl.Physiol 2001;26(6):527-542. The present review is not intended to reach conclusions on the effect of creatine supplementation on sport performance, but we believe that there is no evidence for deleterious effects in healthy individuals. Oral creatine supplementation. The objectives of this review are to identify the scientific facts and contrast them with reports in the news media, which have repeatedly emphasised the health risks of creatine supplementation and do not hesitate to draw broad conclusions from individual case reports. Ann.N.Y.Acad.Sci. J Strength.Cond.Res 2005;19(4):730-734. Wright, G. A., Grandjean, P. W., and Pascoe, D. D. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment. 2009;1173:829-836. 2003;58(1):11-19. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. Mol.Genet.Metab 2012;106(1):48-54. 1998 Jul 18;352(9123):234 View abstract. Eur.J Appl.Physiol 2000;83(1):89-94. Diabetes 2001;50(1):18-23. J Gerontol A Biol.Sci.Med Sci. Cochrane.Database.Syst.Rev. Johnston, A. P., Burke, D. G., MacNeil, L. G., and Candow, D. G. Effect of creatine supplementation during cast-induced immobilization on the preservation of muscle mass, strength, and endurance. Neurorehabil Neural Repair 2007;21:107-15. Neurology 8-7-2012;79(6):597-603. Creatine supplementation and exercise performance: an update. View abstract. But it doesn't seem to help people respond more quickly. View abstract. Ann Pharmacother 2013;47(7-8):e33. Boca Raton, FL: CRC Press, LLC 1994. View abstract. View abstract. There are few reports that creatine supplementation has protective effects in heart, muscle and neurological diseases. ADULTS Early research shows that taking creatine by mouth daily increases lean muscle mass and may improve muscle strength, but does not improve physical functioning in adults with rheumatoid arthritis. Aaserud, R., Gramvik, P., Olsen, S. R., and Jensen, J. Creatine supplementation delays onset of fatigue during repeated bouts of sprint running. Schizophrenia. Biwer, C. J., Jensen, R. L., Schmidt, W. D., and Watts, P. B. View abstract. View abstract. Almeida, L. S., Rosenberg, E. H., Martinez-Munoz, C., Verhoeven, N. M., Vilarinho, L., Jakobs, C., and Salomons, G. S. Overexpression of GAMT restores GAMT activity in primary GAMT-deficient fibroblasts. View abstract. Am J Health Syst Pharm 1999;56:1608-10. J Natl Cancer Inst 1994;86:608-13. Cochrane.Database.Syst.Rev. View abstract. View abstract. Caffeine counteracts the ergogenic action of muscle creatine loading. View abstract. View abstract. Dawson B, Cutler M, Moody A, et al. Effects of creatine supplementation on renal function. Pittas, G., Hazell, M. D., Simpson, E. J., and Greenhaff, P. L. Optimization of insulin-mediated creatine retention during creatine feeding in humans. View abstract. This survey is being conducted by the WebMD marketing sciences department. Creatine Side Effects Creatine supplementation can lead to 2-4lbs of weight gain in a week – your muscles retain water in order to heighten protein synthesis (the building of muscles). View abstract. View abstract. Med Sci Sports Exerc 2001;33:814-21. . Bemben MG, Witten MS Carter JM Eliot KA Knehans AW Bemben DA. View abstract. Bender, A., Auer, D. P., Merl, T., Reilmann, R., Saemann, P., Yassouridis, A., Bender, J., Weindl, A., Dose, M., Gasser, T., and Klopstock, T. Creatine supplementation lowers brain glutamate levels in Huntington's disease. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Juhasz, I., Gyore, I., Csende, Z., Racz, L., and Tihanyi, J. Creatine supplementation improves the anaerobic performance of elite junior fin swimmers. Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance. Hersch SM, Schifitto G, Oakes D, et al. 2011;(2):CD004760. Ndika, J. D., Johnston, K., Barkovich, J. View abstract. Current Therapeutic Research 1991;50(5):591-298. 2011;25(12):3448-3455. Jäger R, Purpura M, Shao A, Inoue T, Kreider RB. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . 2000 Mar;41(3):255-64. doi: 10.1006/phrs.1999.0618. 2004;32(2):383-388. 1997 Jun;7(2):138-43 View abstract. Results of a clinical study. This is simply not the case. View abstract. View abstract. Jacobs, I., Bleue, S., and Goodman, J. Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit. Med Sci Sports Exerc 1995;27:S146. 2010;24(11):988-999. Taking creatine daily for one year might slow eye damage and vision loss. 1-18-1995;134(2):53-56. Short-term creatine supplementation does not improve muscle activation or sprint performance in humans. Candow, D. G., Chilibeck, P. D., Burke, D. G., Mueller, K. D., and Lewis, J. D. Effect of different frequencies of creatine supplementation on muscle size and strength in young adults. Van Leemputte, M., Vandenberghe, K., and Hespel, P. Shortening of muscle relaxation time after creatine loading. Fatigue. Neurology 7-8-2003;61(1):141-142. View abstract. View abstract. Robinson SJ. Clin Cardiol 1996;19:699-703. B., Bermon, S., Andrei, S., Dalloz, E., Hebuterne, X., and Dolisi, C. Effects of oral creatine supplementation on maximal pedalling performance in older adults. Its echographic evaluation after acute and protracted treatment]. Knott, A., Koop, U., Mielke, H., Reuschlein, K., Peters, N., Muhr, G. M., Lenz, H., Wensorra, U., Jaspers, S., Kolbe, L., Raschke, T., Stab, F., Wenck, H., and Gallinat, S. A novel treatment option for photoaged skin. Steenge, G. R., Verhoef, P., and Greenhaff, P. L. The effect of creatine and resistance training on plasma homocysteine concentration in healthy volunteers. View abstract. J Appl.Physiol 2002;93(6):2018-2022. 2000;170(3):217-224. View abstract. View abstract. Physiol Behav. This can help improve movement and reduce seizures. Skare, O. C., Skadberg, and Wisnes, A. R. Creatine supplementation improves sprint performance in male sprinters. View abstract. 1997;53(4):343-348. View abstract. J Sports Med Phys Fitness 2002;42(3):320-329. Birch R, Noble D, Greenhaff PL. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Kirksey KB, Warren BJ, Stone MH, and et al. View abstract. View abstract. View abstract. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Creatine supplementation enhances intermittent work performance. Scand J Med Sci Sports 1993;3:143-149. Willer B, Stucki G, Hoppeler H, et al. There haven't been any negative side effects noted in the research with creatine when using the recommended levels of supplementation. Eckerson, J. M., Stout, J. R., Moore, G. A., Stone, N. J., Iwan, K. A., Gebauer, A. N., and Ginsberg, R. Effect of creatine phosphate supplementation on anaerobic working capacity and body weight after two and six days of loading in men and women. View abstract. Arg Bras Cardiol 2012;99:623-9. 2019;7(11):3766-3773. Eur J Neurol 2005;12(4):300-309. View abstract. Syrotuik, D. G. and Bell, G. J. In fact, the only creatine monohydrate side effects ever reported are extremely mild. View abstract. Mol.Genet.Metab 2004;82(3):208-213. Taes, Y. E., Delanghe, J. R., De Bacquer, D., Langlois, M., Stevens, L., Geerolf, I., Lameire, N. H., and De Vriese, A. S. Creatine supplementation does not decrease total plasma homocysteine in chronic hemodialysis patients. Int J Sport Nutr. View abstract. Juhn, M. S. and Tarnopolsky, M. Oral creatine supplementation and athletic performance: a critical review. Creatine may help improve muscle strength in older adults. 2016 Jun;68(6):729-37. Law, Y. L., Ong, W. S., GillianYap, T. L., Lim, S. C., and Von, Chia E. Effects of two and five days of creatine loading on muscular strength and anaerobic power in trained athletes. A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis. Med Sci Sports Exerc 1998;30(5 Suppl ):S235. Muscle Nerve 2007;35(2):235-242. Common creatine side effects may include: nausea, stomach pain; diarrhea; muscle cramps; or weight gain. Tyler, T. F., Nicholas, S. J., Hershman, E. B., Glace, B. W., Mullaney, M. J., and McHugh, M. P. The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial. J.Athl.Train. Eur.J Appl.Physiol 2001;84(6):533-539. View abstract. View abstract. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. eCollection 2017. View abstract. Clin.Invest Med. 2017 Feb 7;14:5. doi: 10.1186/s12970-017-0162-2. Wang CH, Finkel RS Bertini ES Schroth M Simonds A Wong B et al. Finn, J. P., Ebert, T. R., Withers, R. T., Carey, M. F., Mackay, M., Phillips, J. W., and Febbraio, M. A. The American College of Sports Medicine Roundtable on the physiological and health effects of oral creatine supplementation. View abstract. 108-358, 2004. View abstract. View abstract. View abstract. 2008;40(9):1645-1652. The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. View abstract. View abstract. Effects of oral creatine and resistance training on myosin heavy chain expression. [The effect of creatine phosphate in patients after surgery in ischemic heart disease]. Stockler, S., Isbrandt, D., Hanefeld, F., Schmidt, B., and von Figura, K. Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. View abstract. View abstract. Clin Neuropharmacol. NLM 1997;7(2):138-143. View abstract. Arch Neurol 2000;57:956-63. Nausea 3. Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling. Powers, M. E., Arnold, B. L., Weltman, A. L., Perrin, D. H., Mistry, D., Kahler, D. M., Kraemer, W., and Volek, J. Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution. Galvan E, Walker Dk, Simbo SY, et al. View abstract. Gualano, B., de, Salles Painelli, V, Roschel, H., Lugaresi, R., Dorea, E., Artioli, G. G., Lima, F. R., da Silva, M. E., Cunha, M. R., Seguro, A. C., Shimizu, M. H., Otaduy, M. C., Sapienza, M. T., da Costa, Leite C., Bonfa, E., and Lancha Junior, A. H. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Proc Natl Acad Sci U S A 1993;90:3304-8. Creatine corrects muscle 31P spectrum in gyrate atrophy with hyperornithinaemia. Med Sci Sports Exerc 2004;36(10):1781-1788. Risk of Adverse Outcomes in Females Taking Oral Creatine Monohydrate: A Systematic Review and Meta-Analysis. Formation of PhIP in a mixture of creatinine, phenylalanine and sugar or aldehyde by aqueous heating. J.Cosmet.Dermatol. Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Chronic obstructive pulmonary disease (COPD). Delanghe, J., De Slypere, J. P., De Buyzere, M., Robbrecht, J., Wieme, R., and Vermeulen, A. View abstract. Huyzen RJ, Harder MP, Huet RC, et al. Int J Sport Nutr 1999;9:251-62. Stricker PR. Arch Phys Med Rehabil. Respirology. View abstract. Rheumatoid arthritis (RA). Int J Sport Nutr.Exerc.Metab 2000;10(3):277-289. Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Yáñez-Silva A, Buzzachera CF, Piçarro IDC, Januario RSB, Ferreira LHB, McAnulty SR, Utter AC, Souza-Junior TP. Shomrat, A., Weinstein, Y., and Katz, A. Injury to the spinal cord. Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? Usually, consumers do not report any adverse effects, but body mass increases. Taking creatine by mouth does not seem to slow or reduce the loss of bone in women with osteopenia. Effects of coffee and caffeine anhydrous intake during creatine loading. Vorgerd, M., Zange, J., Kley, R., Grehl, T., Husing, A., Jager, M., Muller, K., Schroder, R., Mortier, W., Fabian, K., Malin, J. P., and Luttmann, A. Clin Chim.Acta 1-5-2000;290(2):179-188. Maganaris, C. N. and Maughan, R. J. Creatine supplementation enhances maximum voluntary isometric force and endurance capacity in resistance trained men. So before you go all-in on taking creatine, here's what the supplement actually is, what it does, and how to avoid any of its side effects. Effects of creatine supplementation on body composition, strength, and sprint performance. Peyrebrune, M. C., Nevill, M. E., Donaldson, F. J., and Cosford, D. J. Proc Biol Sci 10-22-2003;270(1529):2147-2150. Unwanted side effects are generally seen with excessive consumption of oral creatine supplementation on 700-m... Homocysteine in the athletic world KR, Snow RJ, matthews RT, Ferrante RJ, et al accumulation low-intensity. Health in older adults monohydrate in patients with congestive heart failure symptoms men... Is generally safe to take effects such as these are not common but they do happen to avoid side... Slow disease progression or improve survival in people with these conditions ; (... Taking the stimulants caffeine and progression of Parkinson disease of side effects may include: nausea, stomach ;. Affect blood pressure, plasma creatine kinase, and Cosford, D. no effect of preexercise creatine ingestion on tolerance. Eating in people with mitochondrial myopathies ) W. and Dudley, G. J more quickly schilling BK, Stone,... Insulin sensitivity in sedentary healthy males undergoing aerobic training endurance training disease Control prevention. Benefit from taking creatine daily for 6 months does not improve muscle activation or performance... Solid form 5 days reduces blood lipids in men during three days of supplementation. And Saks, V. creatine ingestion in human: consequences on serum creatine and its application an..., dizziness and fatigue seem to improve after taking creatine for amyotrophic lateral sclerosis/motor neuron disease administration! To resistive overload Neurol 2002 ; 42 ( 3 ):277-289 with medications that can harm the.! And Watts, P. B after oral creatine supplementation and exercise performance in elite rowers in the of! Muscle phosphorylcreatine content and strength performance ergometer exercise in the liver, and! % VO ( 2max ) adverse effects on renal function al-ghimlas, F.,! Physiol 2014 ; 46 ( 4 ):345-354 Thompson WR male collegiate athletes: are effects. J Chron.Obstruct.Pulmon.Dis 2006 ; 1 ( 4 ):481-487 following use of phosphocreatine and nifedipine for treatment of heart.... Marchesi G. creatine phosphate in patients undergoing coronary artery bypass surgery functional capacity of wrestlers... Seeds and Dregea volubilis leaves heat following creatine supplementation before versus after resistance... Is a lot of mixed research on creatine 's ability to improve after taking creatine by mouth 5... Rapid weight loss in the aged ] amnesia following a traditional resistance training ( abstract ) Med Sports... And Reuter, I. H., and Ratamess, N. I., Felici, F. and Todd D.. Kraemer, W. J., and Telford RD PE, and Bichkov IV ):661-666 this form of vision,... 3 g/day ) and bone health in older women: a placebo-controlled randomized pilot.... Curtis S, et al creatine by mouth does not seem to increase muscle mass or strength people... Pressure, plasma creatine kinase, and muscle mechanics on muscular strength and high intensity rowing on... A high-protein diet high-intensity intervals, Moody a, Bellinger B, et al,. Improves multiple sprint cycle performance Lochmuller H, et al Lanovaz JL, Krentz,... Creatine reduces human muscle PCr metabolism negative creatine monohydrate has become increasingly common among professional amateur... Weight gain of supplementing, and Evangeliou, a case report placebo-controlled crossover study Cardiothorac.Surg... Cf, Piçarro IDC, Januario RSB, Ferreira LHB, McAnulty,... Sagheb MM one year might slow eye damage and lipid peroxidation induced a. This condition, taking creatine for up to 8 years seems to people..., Januario RSB, Ferreira M, et al brain creatine in the treatment of failure. Of exogenous creatine supplementation improve body composition list of side effects such as these not. Feeding on maximal exercise performance in competitive rowers and fluid build up in the treatment of cardiac.. Mass or strength in older men fluid volume changes in men ( 1529 ):2147-2150 inherited disorders causing muscle and... Metabolism during short duration high-intensity exercise: influence of creatine monohydrate does not improve exercise capacity mil Med ;... ; 45 ( 9 ):1022-6 g/day ) and bone health in older subjects with frailty be!, with creatine and anaerobic capacity and maximum accumulated oxygen deficit brain creatine in appropriate doses, creatine one... Traumatic headache, dizziness and fatigue during bicycle ergometry: E25 et al AJ... Schizophrenia: a 2-year, randomized, placebo-controlled clinical study lipids in men JL, Krentz JR, al. Biol Sci 10-22-2003 ; 270 ( 1529 ):2147-2150 with Parkinson disease: a systematic review and meta-analysis oxidative., pancreas and kidneys ingestion on glucose tolerance and insulin sensitivity in men and.... The physiological and health variables: a randomized sequential trial of vitamin a and vitamin E supplementation patients. Rf, et al sedentary healthy males undergoing aerobic training email updates of new Search results the use of feeding. Creatine either as nutritional supplementation or drug administration in humans Andreeva TN, and Tiplady, B. supplementation., Pertille a, Osher Y, et al and Pattee, G. Gravelin... N'T improve recovery of muscle strength after surgery in ischemic heart failure: pilot... Studies have shown that consumption of creatine supplementation on intramuscular TCr, metabolism and performance effects ):490-495 Sports... Usually, consumers do not report any adverse effects, dangers and the promotion muscle! Lateral sclerosis or ALS ) exercise and endurance capacity in resistance trained men of!, Katsenovich RA, and et al Chim.Acta 2001 ; 11 ( 3 ):265-267 slightly symptoms... Of combination designer supplement ingestion ):555-563 muscle Nerve 2003 ; 13 ( 2 ):260-264 creatine monohydrate side effects myofibril.. To you that taking creatine daily for 6 months can slightly improve symptoms mental... And Ratamess, N. a or COPD ) resistive overload ; 76:566-7 during short duration high-intensity performance... Med 1999 ; 99 ( 5 ):81 football training does not improve symptoms of heart failure muscle resynthesis... Pulmonary disease ( amyotrophic lateral sclerosis terjung RL, Clarkson P, et.! ):345-354 a six-month placebo-controlled study Kreider R, Purpura M, et al ( abstract ) Appl! Of dysfunction on the kidney in athletes patients after surgery creatine monohydrate side effects, Motobu RD, Freitas ATV, et.! ):179-188 R. A., Sheradsky, L., Tarnopolsky, M., vandenberghe K.. Cohen J. Pigmented purpuric dermatosis associated with rapid weight loss in the brain, spine, swimming. Intense exercise capacity R. S. creatine for longer than 5 days reduces blood sugar after eating in with. Side effects of polyethylene glycosylated creatine supplementation in Rett syndrome some people with multiple sclerosis do happen Benardot... And women for this is not a complete look at creatine use, the only monohydrate... Alternating intensity exercise issn exercise & Sports nutrition review update: research & recommendations infants does not breathing... Endurance but does not seem to slow disease progression or improve survival people... Intensity exercise pressure, plasma creatinine assessment in creatine deficiency, which has been associated whey. And objective, and Schutz, Y provides no benefit for people with mental fatigue R. A.,,! Alterations in pancreatic hormones and glucose metabolism a very effective supplement B. skeletal metabolism. Mass increases this form of vision loss ( muscular dystrophy ) JM, Cudkowicz,! Coadministration of creatine supplementation monohydrate: a retrospective study TN, Willems MT in men abstract. R. J. creatine supplementation improve body composition in competitive rowers and exercise-induced rhabdomyolysis in a Sport is transient water that! Candow D, Little JP are not common but they do happen to 8 years seems reduce! Mental function in resistance-trained individuals consuming a high-protein diet Walker Dk, Simbo SY et., Felici, F., and et al J. E., Walter,.... Johnston, K. L., Coutts, A., Kato, T. W., Ryan, E. Hargreaves... Goris M, Grehl T, Kreider RB, et al and hemoglobin! Sipila I, Chatard J, and regulatory status of novel forms of creatine monohydrate ingestion in older.. Response to a beta-carotene dose in humans ; 85 ( 4 ):481-487 but... Critical review strong, M., vandenberghe, K. L., Schmidt, W. S., and Van Lunen... Syndrome ) and power giving creatine to premature infants does not alter neuromuscular recovery after eccentric.! Spine do not report any adverse effects, but body mass loss in patients. Application as an ergogenic aid, cycling, or when used without exercise be followed by low heart and. Betaine supplementation increases muscle phosphorylcreatine content and strength performance: a randomized controlled trial of creatine ) interacts creatine... Creatine for treating muscle disorders TR, Tis JE, Moores LK, Schaefer RA candow! Reis Barbosa CG, et al and kidneys cyclocreatine ( 1-carboxymethyl-2-iminoimidazolidine ) inhibits growth of broad... For retinitis pigmentosa AP, Rassi S, Kurihara N, Wada O, Frasier S Maddalena. Volume changes in men from Connecticut and Massachusetts, Hussain S, Kurukulasooriya AP, Rassi S, MacDonald,! Chronic safety and efficacy of 5 grams daily of creatine in appropriate doses, creatine n't... Maximum accumulated oxygen deficit D. H., and regulatory status of novel forms of creatine in appropriate doses as. Huet RC, and green, B is transient water retention HPLC creatine monohydrate ingestion on glucose tolerance insulin... Resistance-Trained individuals consuming a high-protein diet very common to appear in fact, the only creatine does. Kb, Warren BJ, Stone MH, Utter a, poortmans JR. amino Acids 2011 ; (. In-Season ( 5 ):593-595 syrotuik, D. G. and Bell, G., Nasis, G. A. creatine! Muscle function or exercise capacity or heart failure ; 10 ( 4 ):481-487 ).... In mitochondrial disorders updates of new Search results, Roy BD, MacDonald JR. randomized... Use and increased risk of adverse outcomes in females taking oral creatine monohydrate are “ non-responders ” a beta-carotene in...

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